She is the beauty for the people and is considered the Marilyn Monroe of Mexico. She is also a Kumbia singer and has been nominated for a Latin Grammy. Ninel became even more famous in 2011 with her Twitter and social media draw.
In 2004, Conde participated in the third edition of the reality show Big Brother VIP and was voted-off after 43 days of confinement. In October 2004, she began acting on Rebelde, produced by Pedro Damián. Her most remarkable role so far has been this one. Her role as Alma Rey in Rebelde (2004–2006) expanded her career to Chile, Romania.
In 2005, Conde began appearing on the American dramedy series Ugly Betty where she portrays an actress on a 'faux' telenovela that is seen by the main character's family. She also participated in contest reality show titled El Show de los Sueños, alongside Pee Wee, Kalimba Marichal, Gloria Trevi, DJ Flex/Nigga, Mariana Seoane, and Priscila.
In 2008, she played the character Rosario Montes in Fuego En La Sangre alongside Adela Noriega and Eduardo Yañez. On August 2009 Ninel confirms to appears in Mexican telenovela Mar de amor as Coral (main-villain of the story), the telenovela was produced by Natalie Lartilleux. Conde released her Ayer y Hoy musical project in 2011 and joined the biggest musical of Mexico called, AVENTURERA as the lead. Ninel is working a new regional mexican duets album in late 2012.