Sheryln showed a passion for music at a young age. After winning a local contest called Vamos A Jugar y Cantar, she joined a children-oriented group called K.I.D.S., with fellow Mexican singers Dulce María and Fuzz. K.I.D.S.' second album, En El Principio, was released, and they participated in a tribute album to Pope John Paul II, titled El Pescador.
Sherlyn later began acting in telenovelas.She acted as piojito or Sofía in Marisol. She starred in Clase 406 with Alfonso Herrera, Anahí and Christian Chávez and later starred in Alborada, alongside Lucero. She was cast as Sandy in the Mexican version of Vaselina (Grease), alongside her ex-boyfriend, Aarón Díaz. She was one of the candidates to star as Nessarose in the Mexican version of Wicked but lost the role to Daniela Lujan.
In 2008, she began starring as Rocio in Cuidado con el Angel, alongside William Levy, Maite Perroni and Laura Zapata.
In March 2009, her brother Edgar, who was suffering from terminal cancer committed suicide. Sherlyn spoke about it on the Mexican talk show Hoy, saying We’re extremely sad with the death of my brother. It’s something that you just can never get used to. Unfortunately he had cancer and it was in a really advanced stage. Some people can live with something like that. Others can’t.
On July 27, 2009 the telenovela Camaleones premiered in Mexico in which she stars in with Irvin "Pee Wee" Salinas, Belinda and Alfonso Herrera.
In November 2009 she joined the band Camaleones.